The Boston Terrier breed originated around 1870, when Robert C. Hooper of Boston purchased a dog known as Hooper's Judge, a cross between an English Bulldog and an English White Terrier.

Judge weighed over 30 pounds (13.5 kg.). He was bred down in size with a smaller female and one of his male pups was bred to yet a smaller female. Their offspring interbred with one or more French Bulldogs, providing the foundation for the Boston Terrier. Bred down in size from pit-fighting dogs of the bull and terrier types, the Boston Terrier originally weighed up to 44 pounds (20 kg.) (Olde Boston Bulldogge). Their weight classifications were once divided into lightweight, middleweight, and heavyweight.

The breed was first shown in Boston in 1870. By 1889 the breed had become sufficiently popular in Boston that fanciers formed the American Bull Terrier Club, but this proposed name for the breed was not well received by the Bull Terrier Fanciers. The breed's nickname, "roundheads", was similarly inappropriate. Shortly after, the breed was named the Boston Terrier after its birthplace.

In 1893, the American Kennel Club (AKC) admitted the Boston Terrier breed and gave the club membership status, making it the first American breed to be recognized. It is one of a small number of breeds to have originated in the United States that the AKC recognizes.

The Boston Terrier was the first non-sporting dog bred in America.

In the early years, the color and markings were not very important, but by the 1900s the breed's distinctive markings and color were written into the standard, becoming an essential feature. Terrier only in name, the Boston Terrier has lost most of its ruthless desire for mayhem, preferring the company of humans, although some males will still challenge other dogs if they feel their territory is being invaded.

Boston Terriers enjoyed particular popularity during the 1920's in America.